Dipeptidyl peptidases abolish neuropeptide Y-induced cell death in Ewing’s sarcoma family of tumors
نویسندگان
چکیده
Congyi Lu, Jason U. Tilan, Lindsay Everhart, Magdalena Czarnecka, Steven J. Soldin, Damodara R. Mendu, Dima Jeha, Jailan Hanafy, Christina K. Lee, Junfeng Sun, Ewa IzyckaSwieszczewska, Jeffrey A. Toretsky, Joanna Kitlinska Department of Biochemistry and Molecular & Cellular Biology, Department of Pharmacology, Georgetown-Howard Universities Center for Clinical and Translational Science, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057 Department of Critical Care Medicine, National Institutes of Health, Bethesda, MD, 20892 Department of Pathomorphology, Medical University of Gdansk, Poland Running Head: Neuropeptide Y and dipeptidyl peptidases in Ewing’s sarcoma Address correspondence to: Joanna Kitlinska, Ph.D., 3900 Reservoir Rd., NW, Basic Science Building, Rm 231A, Washington, DC 20057. Fax: 202-687-7407, Email: [email protected]
منابع مشابه
Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV.
Dipeptidyl peptidases 8 and 9 have been identified as gene members of the S9b family of dipeptidyl peptidases. In the present paper, we report the characterization of recombinant dipeptidyl peptidases 8 and 9 using the baculovirus expression system. We have found that only the full-length variants of the two proteins can be expressed as active peptidases, which are 882 and 892 amino acids in le...
متن کاملClinicopathologic characteristics and outcome of childhood and adolescent Ewing’s sarcoma in center of Iran
Background Ewing’s sarcoma family is a group of small round cells tumors. The aim of this study is to evaluate clinicopathologic characteristics and outcome of Ewing’s sarcoma in children and adolescents in Yazd, Iran. Materials and Methods All patients under 19 years with documented pathology of Ewing’s sarcoma family tumor who referred to Shahid Ramazanzadeh Radiotherapy center between 2...
متن کاملEwing's Sarcoma Induction of Cell Death by Basic Fibroblast Growth Factor in
Ewing’s sarcoma is thought to arise after developmental arrest of primitive neural cells during embryogenesis. Because basic fibroblast growth factor (bFGF) has a critical role in the regulation of cell survival, proliferation, and differentiation during embryogenesis, we have tested the hypothesis that bFGF and FGF receptors may contribute to the development of Ewing’s sarcoma and may provide ...
متن کاملDipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans.
A dipeptidyl-peptidase IV was purified from the culture medium of the human-pathogenic fungus Aspergillus fumigatus. The enzyme has an apparent molecular mass of 95 kDa and contained approximately 10 kDa of N-linked carbohydrate. This glycoprotein is antigenic and has all characteristics of the class IV dipeptidyl-peptidases: removal of Xaa-Pro and to a lesser extent Xaa-Ala dipeptides from the...
متن کاملChromosomal translocations that create fusion oncogenes have long been recognized as a cause of human cancers such as leukemias
Chromosomal translocations that create fusion oncogenes have long been recognized as a cause of human cancers such as leukemias and sarcomas (Mitelman et al., 2007), and recently have been described in prostate (Tomlins et al., 2005; Brenner and Chinnaiyan, 2009) and lung cancer (Soda et al., 2007). Drugs that target oncogenic fusions have also led to dramatic improvements in the treatment of c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011